Ueda et al, Trafficking-defective HCN4 mutation in cardiac arrhythmia - 1 - Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia Running title: Trafficking-defective HCN4 mutation in cardiac arrhythmia

1 Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia Running title: Trafficking-defective HCN4 mutation in cardiac arrhythmia Kazuo Ueda, Kazufumi Nakamura, Takeharu Hayashi, Natsuko Inagaki, Megumi Takahashi, Takuro Arimura, Hiroshi Morita, Yasushi Higashiuesato, Yuji Hirano, Michio Yasunami, Shuichi Takishita, Akira Yamashina, Tohru Ohe, Makoto Sunamori, Masayasu Hiraoka, and Akinori Kimura Department of Molecular Pathogenesis, Medical Research Institute, and Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan, Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan, Department of Thoracic and Cardiovascular Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan, Department of Cardiovascular Medicine, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan, Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan, Third Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan